How can I measure and diagnose performance bottlenecks in a Backbone.js application?

When working with Backbone.js, identifying slowdowns often involves measuring model set operations, view rendering times, and event handling overhead. What tools or techniques (e.g., console.time, Chrome DevTools Performance panel, custom instrumentation) are recommended for collecting quantitative data on these components, and how can the results be interpreted to guide optimizations such as debouncing events, reducing DOM manipulations, or minimizing unnecessary sync calls?